000			01788nam a22001577a 4500
082			_a610
100			_aJatala, Faria Hasan _9122408
245			_aFunctional Characterization Of Risk Factor Involved In Mptp-Induced Parkinsonism In Mice / _cFaria Hasan Jatala
264			_aIslamabad : _bSMME- NUST; _c2022.
300			_a72p. _bSoft Copy _c30cm
500			_aThe second-most prevalent neurological disease in the world, Parkinson's disease (PD) affects roughly 4 million people. The death and loss of dopaminergic neurons in the substantia nigra compacta (SNpc) is the primary pathogenic characteristic of PD. Motor abnormalities include limb stiffness, tremor, and bradykinesia are the major features of PD. Although levodopa (L-DOPA) is the gold standard medication, but it has clear negative effects when taken over an extended period. Therefore, it is vital that novel medicines and ideal therapeutic agents be discovered. Parkinson's disease remains an unsolved clinical problem, as currently authorized PD therapies offer relatively modest therapeutic benefits. New therapeutic approaches that not only alleviate symptoms in the short term but also stop the disease from getting worse are desperately needed. For this purpose, mice model is utilized for PD induction by MPTP neurotoxin for functional characterization of proteomic factor GFAP as a risk factor in an effort to enhance the efficacy of the treatment of PD. In future, by targeting pathway of GFAP level in substantia nigra with some targeted drug will eventually lead to innovative therapeutic approach for PD patients.
650			_aMS Biomedical Sciences (BMS)
700			_aSupervisor : Dr. Saima Zafar _9122351
856			_uhttp://10.250.8.41:8080/xmlui/handle/123456789/31048
942			_2ddc _cTHE
999			_c608901 _d608901